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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Revuz J, Clerici T

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While the prescribing information for GLP-1 medications does not specifically list Crohn's disease as a contraindication, the Summary of Product Characteristics (SmPC) for these medicines does advise caution in patients with gastrointestinal disease and states they are not recommended in severe gastrointestinal disease

However, the same mechanisms that help with weight management are also responsible for the digestive side effects many users experience particularly constipation