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Moreover, tirzepatide outperformed dulaglutide for weight loss in type 2 diabetes (Frias et al., 2018), although it is difficult to ascribe this to biased GLP1 receptor agonism due to the potential for GIPRinduced appetite suppression (Adriaenssens et al., 2019) and the fact that the large molecular size of dulaglutide may limit access to appetite regulatory centres to a greater extent than with tirzepatide
& Quarmby, V
LEPR mutations are inherited via autosomal recessive inheritance, so that the parents may not show any sign of the disorder but act as carriers, while the offspring may show the clinical spectrum of this condition
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