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The Real Reasons Perimenopause Causes Weight Gain Now lets get into the mechanismsthe actual physiological changes that make weight gain almost inevitable during perimenopause if you dont adapt your approach: 1

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This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal.[19] By preventing breakdown of GLP-1 and GIP, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas