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This gives it a half-life long enough to support once-weekly dosing, a major practical advantage over earlier amylin-based therapies like pramlintide, which required multiple daily injections

This is noteworthy as (1) many biologically active peptides contain an -helix (a large fraction of PPIs involve an -helix) and (2) those helix portions could potentially be replaced or partially replaced by oligoureas with minimal effect on the binding while improving the proteolytic resistance of the peptide

Melanoma is a disease in which malignant (cancer) cells form in melanocytes (cells that color the skin)

As metabolic efficiency increases, the rate of fat loss slows, even when treatment and healthy habits remain consistent

These same peptides improve skin health, reduce inflammation, and promote wound healing