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This may affect a possible transferability to the outpatient population

doi: 10.1038/s41586-020-2732-8 105 PiattiniFMatsushitaMMuriJBretscherPFengXFreigangSet al

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In agreement with the high density of L-cells in the distal part of the small intestine, from where the so-called ileal brake mechanism (upper gastrointestinal inhibition elicited by distal stimulation) is elicited, it appeared that GLP-1 might be one of the hormones behind it (69), sending inhibitory signals to the brain and proximal GI tract upon arrival of nutrients to the distal small intestine