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Data Collection and Charting Study Selection To identify the studies to be included, two authors (CEBM and AFSR) independently scanned the title and abstract of every record retrieved in the search

Two major clinical trials are the basis for most of what's known about these medications' weight-management effects: STEP 1 (68-week randomized study, adults without diabetes): semaglutide 2.4 mg produced an average loss of roughly 15% of body weight, versus about 2.4% with placebo, alongside a reduced-calorie diet and increased physical activity