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NHS availability would require successful Phase 3 trials, marketing authorisation, and a positive NICE health technology appraisal

Insulin sensitizers, antioxidants, incretin-based drugs, lipid lowering agents, weight loss medications, bariatric surgery and liver transplantation are therapeutic options that can be added to lifestyle interventions when necessary for management of cases

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or signs of a serious allergic reaction

For instance, in the FLOW trial, only 277 participants in the combination group compared to 1,490 receiving semaglutide alone