For now though, let's go kick stuff off with a friendly WADA (World Anti-Doping Agency) approved (or at least not banned at the time of writing) compounds in the GLP-1s
Heres what the research and my clinical experience reveal: Semaglutide is a well-established option with: Weekly injections Proven safety profile Average weight loss of 15-20% of body weight Effective appetite suppression Improvements in cardiovascular health markers Tirzepatide offers: Weekly injections Potentially greater weight loss (16-22.5% of body weight) Dual-action mechanism Similar side effect profile to semaglutide Enhanced metabolic benefits In a recent head-to-head trial , tirzepatide demonstrated superior weight loss compared to semaglutide, with participants losing an average of 20.2% versus 13.7% of their body weight at 72 weeks
L-carnitinesupplementation also prevents the progression ofheartmuscle damage in people with congestiveheartfailure and improves exercise tolerance in people who develop chest pain (angina) with exertion
doi: 10.3389/fphys.2025.1693589
In the SURPASS-4 trial, tirzepatide significantly decreased blood pressure, body weight, and HbA1c, and its dual-receptor agonism improved lipid profiles, increased insulin secretion, reduced inflammation, and promoted endothelial integrity (32)
