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Across these areas, results remain preliminary but encouraging

A single intragastric alcohol dose caused gastric lesions, brain swelling, intracranial hypertension, liver and kidney damage, lung injury, and severe thrombosis

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As a result, oxyThDP inhibits ThDP-dependent dehydrogenases, whose function is required for ACh synthesis, particularly pyruvate dehydrogenase complex generating ACh precursor acetyl-CoA (Figure 1)

Collectively, the rising prevalence of MASLD, ALD and MetALD has made these conditions the fastest-growing cause of HCC and among the leading reason for liver transplantation worldwide (Ochoa-Allemant et al., 2025