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Most events were mild or moderate

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These findings may inform appropriate expectation setting for patients and clinicians and highlight the need for better methods of treatment selection for patients with degenerative lumbar spinal stenosis. Surgery caused adjacent segment disease A December 2025 study ( 20 ) explained that lateral lumbar interbody fusion (LLIF) works by indirectly providing decompression by restoring disc height

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Comparing the two is a study in how much the specific GCGR-to-GLP-1R ratio and the escalation schedule matter to the clinical profile