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Interestingly, acetylation signals for the mutants SnCE1 K231R, SnCE1 E217D K231R and of the gatekeeper SnCE1 W191A were strongly reduced suggesting a potential structural role interfering with (acetyl-)CoA binding (Fig

Within mitochondria the enzyme glutaminase (GLS) acts on glutamine to produce -ketoglutarate (-KG), and -KG subsequently enters the TCA cycle to support energy production and anaplerosis

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