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Incretin signalling and biased agonism: Basic concepts Both GLP-1 and GIP stimulate insulin secretion from pancreatic beta cells, with GIP also stimulating alpha cells to secrete glucagon (Manchanda et al., 2022)

Further, GSH can be regenerated by GR using nicotinamide adenine dinucleotide phosphate (NADPH) as the substrate (Fig

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In 2025, the American Association of Clinical Endocrinology updated its Obesity Algorithm, which highlights the importance of preserving skeletal muscle during medical weight-loss interventions: patients who retain strength tend to experience fewer side effects, more energy, and better long-term weight maintenance