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Further support for these findings came from an ex vivo skin model, which also showed a notable increase in collagen 4 synthesis at the dermal-epidermal junction when exposed to the optimized GHK-Cu and LMW HA mixture

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doi:10.1016/S0190-9622(98)70547-X

The transient receptor potential (TRP) channels on the cell surface allow Ca 2+ influx to initiate the NF-B-dependent inflammatory responses, which can be triggered by environmental irritants such as inflammatory cytokines and pathogens [61,62,63]

Palmer, N