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Skin tone usually returns gradually to its natural baseline if treatments are discontinued

Additionally, as we are considering evaluating and updating the CY 2026 qualifying non-opioid treatments for pain relief, we are modifying the regulation text accordingly

Epidermal PIH may resolve better and faster than dermal PIH where melanin accumulates in long-lived melanophages [27]. Melasma is also a chronic acquired hypermelanosis which involves increased melanin levels in the epidermis and/or dermis [28,29,30]. It manifests as bilateral dark or grayish-brown macules, more particularly located on the face

It goes deeper than that

theyre driven by underlying biological factors like dopamine balance, stress levels, and sleep quality