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Critical nodes in signalling pathways: insights into insulin action

Tirzepatide produces weight reduction through GLP-1 and GIP receptor activation, which delays gastric emptying, reduces appetite signaling, and improves insulin sensitivity

Acknowledgments I would like to express my deepest gratitude to the following individuals who have contributed to the completion of this article

Gallbladder disease, including cholelithiasis (gallstones) and cholecystitis (inflammation of the gallbladder), has been reported in individuals using tirzepatide

10.1016/j.cell.2015.05.002 18 MantelP.-Y.HjelmqvistD.WalchM.Kharoubi-HessS.NilssonS.RavelD.et al (2016)