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doi:10.1001/jamaneurol.2013.1425

Nevertheless, achieving therapeutic efficacy with AAV often requires high viral titers, raising potential issues of dose-dependent cytotoxicity, immune responses, and eventual transgene silencing (179)

Additionally, FSP1 catalyzes the reduction of coenzyme Q10 (CoQ 10 ) or vitamin K into their reduced forms, CoQH 2 or VKH 2 , which function as antioxidants to suppress ferroptosis [5, 15]

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