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349 Dietary modifications and pharmacologic strategies targeting symptoms are considered to improve life quality despite no alterations in the underlying pathology or natural history of this disease

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l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiotadependent formation of trimethylamine (TMA) and trimethylamine N -oxide (TMAO) via a multistep pathway involving an atherogenic intermediate, -butyrobetaine (BB)