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Chronic treatment with the co-agonist also improved glucose tolerance and insulin secretion in cynomolgus monkeys and humans [91]

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Also, in the experiments on human breast cancer cells, Won and Seo found that the inactivation of PI3K/Akt/mTORC1 signaling pathway promotes the expression of caspases and Bax leading to increased apoptosis [302]

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Jurga et al., 2020