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There were two further phase IIa studies evaluating cotadutide with the first one showing that it reduced glucose levels in those with obesity and T2DM with the mechanism being greater insulin secretion and delayed gastric emptying [46]

Interestingly, GHK alone appeared to produce a comparable stimulatory action, while copper(II) ions in isolation may indicate no such activity, suggesting the tripeptide moiety may be the primary active component, possibly reforming complexes with trace copper present in the culture medium