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Because these medications slow down digestion, the most common side effects are gastrointestinal

Radziuk J, Pye S (2001) Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis

& Sokolowski, C

Long-term use at very high doses and interactions with certain medications (particularly nitroglycerin and potentially anticoagulants) warrant provider guidance

The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9