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For instance, co-administering CUR with PPR or RSV significantly enhances CURs bioavailability, amplifying its anti-inflammatory (33), apoptotic, and anticancer effects (34, 97)

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FADT: flavin adenine dinucleotide transporter After cellular uptake, free riboflavin undergoes adenosine triphosphate (ATP)-dependent phosphorylation by riboflavin kinase (RFK) (EC 2.7.1.26), a ubiquitous rate-limiting flavokinase, to form FMN, which is consequently adenylated to FAD by FAD synthase (FADS) (EC 2.7.7.2)

Conversely, the proteolytic enzyme cathepsin H is induced in TR-expressing hepatoma cells on T3 treatment and its upregulation results in increased cell migration and activation of matrix metalloproteinase or ERK activation