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This can lead to cytokine production for inflammation which, if released, augments permeability, producing a cycle of inflammation

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Inflammation that affects the peripheral nervous system (a network of nerves that runs throughout the head, neck and body), also referred to as neurogenic inflammation, and inflammation that affects the brain and spinal cord, also known as neuroinflammation, are involved in migraines with and without auras and chronic migraines

Palliative care - Treatment focusing on comfort is available when curative treatment is no longer desired