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Lower thalamic GABA levels may trigger migraine attacks in the early years, resulting in chronically higher cortical glutamate levels later in life, perpetuating the migraine cycle throughout adulthood

Diagnosis requires extreme fatigue lasting at least 6 months plus at least four additional symptoms: unrefreshing sleep, cognitive impairment ("brain fog"), muscle pain, joint pain, sore throat, tender lymph nodes, or new headaches

acnes cells can be used as immune stimulants that activate macrophages and mononuclear cells, contributing to an enhanced elimination of pathogens [83]

The GATE 1 trial

Seek urgent medical attention for symptoms that may indicate a severe allergic reaction or another medical emergency