But ApoEs physiological role is complex
Contact your doctor immediately if you experience: Vision problems or blurred vision: These could indicate increased eye pressure or other serious complications Severe mood changes or signs of mental illness: Including depression, anxiety, or unusual behavior Signs of infection: Such as fever, chills, or persistent sore throat Irregular heartbeat or chest pain Severe stomach pain or black, tarry stools that look like coffee grounds Sudden weight loss or significant weight gain Eye pain or changes in vision Symptoms of an allergic reaction: hives, swelling of your face, tongue, or throat, and trouble breathing Other important side effects to monitor include fluid retention (swelling in the lower legs), high blood pressure, and signs of high blood sugar such as increased thirst, urination, or blurred vision
Yang et al., 2012)
IIASA (2024)
Although 11 studies (including nearly 6,000 patients) had a history of suicide attempt/depression as exclusion criteria for enrollment, removal of these studies did not affect the overall findings of the meta-analysis