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It is especially given to patients who are in the ICU or who require parenteral nutrition (nutrition through IV)

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The NLRP3 inflammasome is activated by lipid peroxidation byproducts such as 4-HNE and MDA produced during ferroptosis, triggering caspase-1-dependent maturation of IL-1/IL-18, which amplifies inflammation and establishes a vicious cycle (127, 131)