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Cadmium in nicotine triggers inflammatory proteins, reduces energy, and raises ROS, which damages cells, elevates GGT, depletes glutathione, weakens vitamins C and E, and lowers serotonin and melatonin, impacting mood and sleep 47, 48

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Among these antioxidants, GSH seems to be the determining agent because it is selectively decreased in the brains of patients with these neurodegenerative diseases (e.g., Parkinsons disease, Alzheimers disease, and Amyotrophic lateral sclerosis) [74]