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Briefly, cells expressing the corresponding D2-like receptors were treated with the agonist for 15 min (initial treatment) to trigger desensitization and then washed three times with serum-free medium (5 min per wash) at 37 C to remove the receptor-bound agonist

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[32] found that exendin-4 mitigated resistance to the androgen receptor inhibitor enzalutamide in prostate cancer via the PI3K/AKT/mTOR pathway, suggesting that a combination of exendin-4 with enzalutamide may be a more effective therapeutic option for advanced prostate cancer

Research Characteristics: Synthetic analog of melanocyte-stimulating hormone (MSH) Studied for activity at melanocortin receptors involved in pigmentation pathways Examined in laboratory models of pigmentation and photobiological response THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only