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SGLT2i stimulate natriuresis, diuresis, and glucosuria thereby reducing plasma volume and lowering cardiac preload (81,82)
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I believe it relates to health of vagal afferent signaling and GLP-1 resistance
It is a likely reason why the weight loss and liver fat numbers in trials look stronger than older single- or dual-pathway compounds
Estrogen decline reshapes appetite signaling, shifts fat storage toward the middle, and changes how side effects feel, and it does all of this unevenly, sometimes month to month
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