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There are many randomized placebo-controlled studies showing the superiority of these drugs over placebo (15)
Besides their well-known pivotal role in peptide bound formation, C domains have been reported to catalyze ester bound formation and may also have dual functions by acting as epimerization and condensation domain 26,27,28
Buyers should look closely at manufacturing transparency, requesting certificates of analysis and confirming that batches are tested by independent labs rather than relying solely on internal claims
Acknowledgements We thank J
BMJ 330 , 223 (2005)
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