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As Health Canada cleared a second generic semaglutide injection on May 1, 2026, a senior Canadian diabetes researcher urged caution, telling CBC News that semaglutide products are "powerful drugs" that "can be taken in a wrong way" and cause side effects [Source: cbc.ca/news/health/ozempic-semaglutide-generic-version-canada-9.7184915]

Do not stop semaglutide abruptly without guidance, as this can trigger rapid rebound effects

Literature data shows that optimized tri-agonists normalize body weight in diet-induced obesity (DIO) in mice and increase energy expenditure more effectively than GLP1R mono-agonists or GLP1R/GIPR (Gastric inhibitory polypeptide receptor) co-agonists 9

Eating frequent small meals may minimize the side effects

Samples were processed for histology