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In SUSTAIN 6 and PIONEER 6, both powered to demonstrate noninferiority (upper 95% confidence interval [CI] of the hazard ratio [HR] 7% and at high risk of CV events, defined as: i) aged 50 years with established CVD (previous CV, cerebrovascular, or peripheral vascular disease), chronic heart failure (HF) (New York Heart Association [NYHA] class II or III), or chronic kidney disease (CKD) stage 3

GLP-1 Agonists: Maximize the Benefits, Minimize the Risks GLP-1s are among the most powerful tools we have for treating diabetes and obesitybut they're not magic bullets

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Clinical trials have demonstrated the effectiveness of semaglutide compared to other weight loss medications, such as liraglutide, which is also a GLP-1 agonist