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The most common reason for reverting is slower-than-expected progress, suggesting that the glucagon threshold concern is not merely theoretical

The cauda equina nerves serve the bladder and bowel, and any damage to them can cause severe impairment in the lower back and legs, resulting in bladder or bowel incontinence

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The dose is then gradually increased over several weeks

Safety, Provider Oversight, and Who Should Consider HSA-Funded GLP-1 Therapy GLP-1 medications are appropriate for individuals with a BMI of 30 or higher, or BMI of 27+ with comorbidities like hypertension or type 2 diabetes