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Glucagon agonism raises theoretical concerns about hyperglycemia in insulin-resistant populations, though fasting glucose remained stable or improved across all retatrutide arms

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Inject in the same abdominal area, rotating slightly each session

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In REDEFINE 1 (NEJM 2025, n=3,417, 68 weeks), cagrilintide monotherapy at 2.4 mg produced 11.8% mean body-weight reduction versus 2.3% with placebo