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[DOI] [PubMed] [Google Scholar] 77.Williams DL, Bonilla M, Gladyshev VN, Salinas G

A comprehensive workup for fibroids typically includes: estradiol, FSH, LH, progesterone (timed to the luteal phase), SHBG (sex hormone binding globulin), total and free testosterone, DHEA-S, fasting insulin, fasting glucose, CBC with ferritin (to assess iron deficiency anemia from heavy bleeding), 25-OH vitamin D, thyroid panel (TSH, free T4, TPO antibodies), and in selected cases a urinary estrogen metabolite panel (e.g., DUTCH) to assess Phase I and Phase II estrogen metabolism

It is driven by iron-dependent phospholipid peroxidation and regulated by several cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars [67]

Extracellular Matrix (ECM) Remodeling and Collagen Alignment: Investigating the deposition, maturation, and tensile alignment of structural tissue matrices