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This enzyme is involved in protein folding and stability (Pernodet et al., 2012) and several studies have already demonstrated that an over-expression of QSOX1 in different cancer type is also associated with an aggressive disease

In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, Manis M, Ibrahim A, Deng L, Benitez BA, et al