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Under normal physiological conditions, however, GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase IV (DPP-4), giving it a fleeting half-life of just a few minutes

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This is actually a positive sign, since platforms that approve everyone regardless of medical history are cutting corners on safety

When you receive GLP-1 therapy, the medication helps you feel fuller after meals, naturally reducing your calorie intake

They are susceptible to degradation pathways that small molecules simply do not face, including deamidation, oxidation, aggregation, and hydrolysis