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According to FDA labeling and American Diabetes Association guidelines, GLP-1 receptor agonists are indicated for type 2 diabetes (as an adjunct to diet and exercise) and for chronic weight management in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity

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(3) by ensuring intracellular alkalinization of tumoral cells through bicarbonate secretion via carbonic anhydrase IX (CAIX) [90]

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doi: 10.1210/endo.138.11.5476 6 BowersC