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Iron homeostasis is achieved by a concerted action of multiple proteins, whose actions converge on the SMAD signaling pathway controlling the expression of the Hamp gene encoding a suppressor of iron uptake, hepcidin (25)

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Whole-exome sequencing on 13,933 patients with major BD and 14,422 controls identified ultra-rare protein-truncated variants (PTVs) in both BD major subtypes (bipolar I disorder and bipolar II disorder)