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In this sense celecoxib showed to be a safe and a highly effective therapeutical option in resistant bipolar depression, reducing anxiety and accelerating treatment response [335], in a similar way to aspirin [336]

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Uric acid crystals also induce the release of proinflammatory cytokines such as IL-1 4,5 , a signaling molecule secreted when the formation of a high molecular weight complex named inflammasome is activated 6

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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Marino Gammazza A., Legare S., Lo Bosco G., Fucarino A., Angileri F., Oliveri M., Cappello F