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Neutralizing free radicals, supporting detoxification, and maintaining cellular health

When modeling the financial impact of GLP-1 coverage, including potential offsets in cardiometabolic claims, plan sponsors should consider both the high per-member-per-month drug cost and the likelihood that weight and risk factors will revert to baseline after medications are discontinued

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Since DAEs occurred more frequently in semaglutide, it may be due to its longer half-life (165 h), potentially inducing a more abrupt return of hunger when pausing the treatment and leading to permanent discontinuations (Rubino et al., 2022)