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One review and meta analysis found that inositol may help decrease BMI, but only in the short-term and not in a clinically meaningful amount

Lancet Glob Health 12:e1534e1543

IGF-DES and Skeletal Muscle Hypertrophy Research IGF-1 signalling via the PI3K/Akt pathway drives protein synthesis through activation of ribosomal protein S6 and the translation initiation factor eIF4E downstream of mTORC1, and can suppress protein degradation via inhibition of FoxO-mediated transcription of E3 ubiquitin ligases mechanisms that are directly relevant to muscle hypertrophy and atrophy research models in which IGF-DES is employed as a research tool