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The effectiveness of GLP-1 therapies depends not only on their pharmacological properties, but on the ability of patients to integrate them into their lives over the long term

Key results at 80 weeks: Participants on the 4 mg dose lost an average of 47.2 lbs (19.0%) Participants on the 12 mg dose lost an average of 70.3 lbs (28.3%) 45.3% of participants on the 12 mg dose achieved at least 30% weight loss a level historically associated with bariatric surgery outcomes The 4 mg dose showed a lower rate of discontinuation due to adverse events than even placebo In a study extension to 104 weeks, participants with a starting BMI of 35 or higher who received 12 mg lost up to an average of 85.0 lbs (30.3%)

Longitudinal studies comparing incretin and glucagon levels in healthy children compared to children with other metabolic disorders should be further investigated

(Credit: Michael Siluk/UCG/Universal Images Group via Getty Images) But researchers had far less understanding of how small-molecule GLP-1 drugs worked inside the brain

Advanced metabolic research with a wider lens