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Our interpretation of the findings suggests that an extended treatment timeline with potentially increased dosage could enhance weight loss." He further commented, "The preliminary safety and tolerability profiles are proving to be noteworthy, especially pertaining to the minimal gastrointestinal side effects observed

Harvin JA, Lahat G, Correa AM, Lee J, Maru D, Ajani J, Marom EM, Welsh J, Bhutani MS, Walsh G, Roth J, Mehran R, Vaporciyan A, Rice D, Swisher S , Hofstetter W

Patients should be counselled to report persistent gastrointestinal symptoms promptly

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Borbath and coworkers [82] reported the case of a 51-year-old woman who received 10 mg/kg VPA daily to prevent seizures after a neurosurgical procedure, and who developed VHE (ammonia concentration 234 mol/l) without any sign of hepatic dysfunction