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Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation

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Clinical data suggests this effect occurs alongside weight loss and improved glycemic control, though individual responses vary significantly based on baseline metabolic state and genetic factors

(2007) 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

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