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Acknowledgements This research was funded by National Basic Research Program of China (973 program 2014CB138600), National Natural Science Fund (31272676 and 31472290), and Program for New Century Excellent Talents in University

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Circulation 125 , 13561366 (2012)

Chronic treatment with high concentrations of liraglutide (200 and 400 g/kg) and KBP-089 (2.5 g/kg) resulted in a 7 and 15% vehicle-corrected body weight loss, respectively, while the combinations (L 200 g/kg + KBP 2.5 g/kg and L 400 g/kg + KBP 2.5 g/kg) resulted in a 17 and 21% weight reduction, respectively (Fig