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Local injection-site tolerance has been assessed in all setmelanotide toxicity studies, and the most common findings were that inflammatory injection-site reactions related mainly to the primary excipient, mPEG-DSPE, with the possible involvement of setmelanotide at high doses

Jul 2010;25(3):280-8

As patients lose weight on GLP-1 therapy, reductions in fat massespecially around internal organscan enhance the body's responsiveness to insulin

That includes the closely watched Petrelintide drug candidate, which Roche is currently co-developing and co-commercializing as part of a $5.3 billion partnership with Danish biotech Zealand Pharma

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