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Not every intervention works in isolation

Emerging role of GLP-1 agonists in obesity: a comprehensive review of randomised controlled trials

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Although the CIs were wide because of the small number of events in subgroups, point estimates showed that the combination of GLP-1RAs and SGLT2is tended to reduce the incidence of HHF more than either alone

First week: Mild nausea, fatigue, or headaches are most common Weeks 24: Symptoms often lessen as the body adapts After one month: Many people report minimal or no ongoing side effects Side effects may briefly return after dose increases, then improve again