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The actual clinical evidence for resM specifically is still developing, with a randomized, placebo-controlled trial currently in progress at ClinicalTrials.gov

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This accumulation facilitates the binding of -catenin to TCF7L12, triggering the activation of genes associated with osteogenesis.371 In a study examining the effects of GLP-1RA on osteoporosis induced by ovariectomy in aged rats, administering exendin-4 for 16 weeks prevented deterioration of the trabecular microarchitecture and increased bone strength