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What this likely means in practice: This is where meaningful functional improvements would be expected improved range of motion, reduced pain with activity, measurable GI symptom changes

Maan Harbi and colleagues

Treatment with mazdutide was also associated with improvements in metabolic parameters, including reductions in HbA1c (1.27%), fasting glucose levels, blood pressure, and lipid profiles, such as total cholesterol and triglycerides

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This remains an area of active research rather than established clinical practice, and until adequately powered, randomised controlled trials assess the safety and efficacy of this specific combination, clinicians and patients should approach any claims about its benefits with appropriate scepticism