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Thus, further studies are needed to evaluate Canagliflozin as a candidate for repositioning as an anticancer agent, including TC

Many important mediators, such as IL-1 and TNF-, recruit death-inducing signaling complexes via binding with respective ligands, and subsequently activate the caspase signaling pathway, ultimately leading to internucleosomal DNA fragmentation 31,32

This was supported by the evidence that the genetic removal of Mfn2 in POMC neurons results in severe obesity characterized by excessive eating and reduced energy expenditure (66)

However, the evidence is still in its infancy, and further long-term studies are needed

Circu and Aw, 2010